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A multi-kinase inhibitor
Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).1 In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.
1.Xi, N.Substituted quinoline compounds and methods of useUS20120219522A1(2012)
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