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  • QL47
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QL47

QL47不可逆的BTK抑制剂,IC50为7 nM。

原价
¥1212-10775
价格
970-8620
QL47的二维码

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  • 货号: ajce58338
  • CAS: 1469988-75-7
  • 别名:
  • 分子式: C27H21N5O2
  • 分子量: 447.49
  • 纯度: >98%
  • 溶解度: Water: < 0.1 mg/mL (insoluble); DMSO: < 1 mg/mL (insoluble or slightly soluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.IC50 Value: 7 nMTarget: Btkin vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].in vivo: N/A



[1]. Wu, H., et al., Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma. ACS Chem Biol, 2014.

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