Background:
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly suppressed the photoreceptor collapse. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) inhibited the generation of the APP-CTF by affecting APP cleavage. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) prolongs lifespan of significantly in the dose dependent manner[1].
参考文献:
[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127.
[2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.
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