Advanced glycation end products (AGEs)

高级糖基化终产物

英文解释

Advanced glycation end products (AGEs) are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. These compounds biologically act as agonists for these receptors for The receptor for advanced glycation end products (RAGE) and suppress bone metabolism.

中文解释

高级糖基化终产物 (AGEs) 是通过还原糖和胺残基之间的非酶促反应产生的多种化合物，通过它们在骨胶原纤维中的积累对骨材料的性质产生物理影响，骨材料是骨质量的组成部分之一。 这些化合物在生物学上充当这些晚期糖基化终产物受体 The receptor for advanced glycation end products (RAGE) 的激动剂并抑制骨代谢。

参考文献

[1]. Masahiro Yamamoto, et al. Advanced Glycation End Products, Diabetes, and Bone Strength. Curr Osteoporos Rep. 2016 Dec;14(6):320-326.