Angiotensin II (AT-II)

血管紧张素 II

英文解释

Angiotensin II (AT-II), a product of the renin-angiotensin-aldosterone system, is an alternative potent vasoconstrictor without chronotropic or inotropic properties. AT-II alao is a pro-fibrotic compound that acts via membrane-bound receptors (AT-1R/AT-2R) and thereby activates hepatic stellate cells (HSCs).

中文解释

血管紧张素 II (AT-II) 是肾素-血管紧张素-醛固酮系统的产物，是一种替代的强效血管收缩剂，没有变时或变力特性。 AT-II alao 是一种促纤维化化合物，通过膜结合受体 (AT-1R/AT-2R) 发挥作用，从而激活肝星状细胞 (HSC)。

参考文献

[1]. Amar P Jadhav, et al. Angiotensin II in septic shock. Am J Emerg Med. 2019 Jun;37(6):1169-1174.
[2]. Golnar Karimian, et al. Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis. PLoS One. 2012;7(12):e52647.
[3]. Nuttha Lumlertgul, et al. Roles of angiotensin II as vasopressor in vasodilatory shock. Future Cardiol. 2020 Nov;16(6):569-583.