Angiotensin type 1 receptor (AT1)

血管紧张素 1 型受体

英文解释

Angiotensin type 1 receptor (AT1R) is a functional target for non-HLA allo- and autoantibodies (AT(1)R-Abs) comprising of IgG1 and IgG3 subclasses. AT1R is an important pharmacological target in the treatment of cardiovascular disorders, such as hypertension, diabetic nephropathy, cardiac hypertrophy, arrhythmia and failure.

中文解释

血管紧张素 1 型受体 (AT1R) 是由 IgG1 和 IgG3 亚类组成的非 HLA 异型抗体和自身抗体 (AT(1)R-Abs) 的功能靶点。AT1R 是治疗心血管疾病的重要药理靶点，如高血压、糖尿病肾病、心肌肥厚、心律失常和心力衰竭。

参考文献

[1]. Aplin M, et al. Molecular determinants of angiotensin II type 1 receptor functional selectivity. J Mol Cell Cardiol. 2009 Jan;46(1):15-24.