C-terminal binding proteins (CtBPs)

C-末端结合蛋白家族

英文解释

C-terminal binding proteins (CtBPs) family members function predominantly as transcriptional corepressors in association with sequence specific DNA-binding transcriptional repressors. The vertebrates have two CtBP genes while the invertebrates contain a single gene. Genetic studies indicate that the CtBP genes play pivotal roles in animal development.

中文解释

C-末端结合蛋白家族 (CtBPs) 成员主要作为转录辅助抑制子与序列特异性 DNA 结合的转录抑制子相结合。脊椎动物有两个 CtBP 基因，而无脊椎动物只有一个基因。遗传学研究表明，CtBP 基因在动物发育过程中起着关键作用。

参考文献

[1]. Chinnadurai G. Transcriptional regulation by C-terminal binding proteins. Int J Biochem Cell Biol. 2007;39(9):1593-607.