Chromatin immunoprecipitation (ChIP)

染色质免疫沉淀

英文解释

Chromatin immunoprecipitation (ChIP) is a technique whereby a protein of interest is selectively immunoprecipitated from a chromatin preparation to determine the DNA sequences associated with it. ChIP has been widely used to map the localization of post-translationally modified histones, histone variants, transcription factors, or chromatin modifying enzymes on the genome or on a given locus.

中文解释

染色质免疫沉淀 (ChIP) 是一种技术，通过该技术，目的蛋白质从染色质制剂中选择性地免疫沉淀，以确定与其相关的 DNA 序列。ChIP 已广泛用于绘制翻译后修饰组蛋白、组蛋白变体、转录因子或染色质修饰酶在基因组或给定基因座上的定位。

参考文献

[1]. Philippe Collas, et al. The current state of chromatin immunoprecipitation. Mol Biotechnol. 2010 May;45(1):87-100.