Chromatin immunoprecipitation followed by sequencing (ChIP–seq)

染色质免疫沉淀后测序

英文解释

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a technique for studying gene regulation and epigenetic mechanisms. ChIP-seq can realize genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes. It has has the advantage of highe resolution, less noise and great coverage.

中文解释

染色质免疫沉淀后测序 (ChIP-seq) 是一种研究基因调控和表观遗传机制的技术。ChIP-seq 可以实现 DNA 结合蛋白、组蛋白修饰或核小体的全基因组分析。它具有分辨率高、噪音小、覆盖面大等优点。

参考文献

[1]. Park PJ. ChIP-seq: advantages and challenges of a maturing technology. Nat Rev Genet. 2009 Oct;10(10):669-80.