Classical complement pathway (CCP)

经典补体途径

英文解释

Classical complement pathway (CCP) is one of the recognition pathways that activate the complement system. CCP can be activated when the C1 complex (composed of C1q, C1r2, and C1s2) binds to apoptotic cells, neuronal blebs, fAβ, hyperphosphorylated tau, or antigen-antibody complexes. The activation leads to sequential enzyme activation, protein cleavage, and induces protein conformational changes.

中文解释

经典补体途径 (CCP) 是激活补体系统的途径之一。当 C1 复合物 (由 C1q、C1r2 和 C1s2 组成) 与凋亡细胞、神经元泡、fAβ、过度磷酸化的 tau 蛋白或抗原抗体复合物结合时，可以激活 CCP。这种激活会导致后续的酶激活、蛋白质裂解，并诱导蛋白质构象变化。

参考文献

[1]. Schartz ND, et al. The good, the bad, and the opportunities of the complement system in neurodegenerative disease. J Neuroinflammation. 2020 Nov 25;17(1):354.