Clear cell renal cell carcinoma (ccRCC)

透明细胞肾细胞癌

英文解释

Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by genetic mutations in factors controlling hypoxic signaling pathways, resulting in metabolic dysregulation, enhanced angiogenesis, intratumoral heterogeneity, and deleterious tumor microenvironment (TME) crossover.

中文解释

透明细胞肾细胞癌 (ccRCC) 是一种恶性肿瘤，其特征是控制缺氧信号通路的因子的基因突变，导致代谢失调、血管生成增强、瘤内异质性和有害的肿瘤微环境 (TME) 交叉。

参考文献

[1]. Wolf MM, et al. Modeling clear cell renal cell carcinoma and therapeutic implications. Oncogene. 2020 Apr;39(17):3413-3426.