Danger-associated molecular patterns (DAMPs)

危险相关分子模式

英文解释

Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm signals by the innate immune system. DAMPs are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). DAMPs play a role in correcting the altered physiological state.

中文解释

危险相关分子模式 (DAMP) 是坏死或应激细胞的代谢产物改变，被先天免疫系统视为警报信号。 DAMP 是宿主衍生的分子，可以调节病原体识别受体 (PRR) 的激活。 DAMPs 在纠正改变的生理状态中发挥作用。

参考文献

[1]. Seema Patel, et al. Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation. Curr Allergy Asthma Rep. 2018 Sep 28;18(11):63.
[2]. Leslie B Tolle, et al. Danger-associated molecular patterns (DAMPs) in acute lung injury. J Pathol. 2013 Jan;229(2):145-56.