Death-inducing signaling complex (DISC)

死亡诱导信号复合物

英文解释

The death-inducing signaling complex (DISC) is a fundamental multiprotein complex, which consists of different death domain (DD) and death effector domain (DED) containing proteins such as the death receptor Fas (CD95) in complex with FADD, procaspase-8, and cFLIP. DISC triggers the extrinsic apoptosis pathway through stimulation by death ligands.

中文解释

死亡诱导信号复合物 (DISC) 是一种基本的多蛋白复合物，由不同的死亡结构域 (DD) 和死亡效应结构域 (DED) 组成，其中包含与 FADD、procaspase-8 复合的死亡受体 Fas (CD95) 等蛋白质 和 cFLIP。DISC 通过死亡配体的刺激触发外源性细胞凋亡途径。

参考文献

[1]. Sayyed Jalil Mahdizadeh, et al. Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein-Protein Docking Meta-Approach. J Chem Inf Model. 2021 Jul 26;61(7):3543-3558.