Degrader

降解剂

英文解释

Degrader is a compound that result in loss of both enzymatic and non-enzymatic functions of proteins, such as the scaffolding function of kinases or the gene regulatory functions of transcriptional effectors.

中文解释

降解剂是一种能导致蛋白质的酶和非酶功能丧失的化合物，如激酶的支架功能或转录效应器的基因调节功能。

参考文献

[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.