Dihydroorotate dehydrogenase (DHODH)

二氢乳清酸脱氢酶

英文解释

Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes that provides nucleotides for RNA/DNA synthesis essential for proliferation. DHODH also is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. DHODH paly a role in cancer cells proliferation.

中文解释

二氢乳清酸脱氢酶 (DHODH) 是原核生物和真核生物中嘧啶从头生物合成的关键酶，它为 RNA/DNA 合成提供增殖所必需的核苷酸。DHODH 还是嘧啶酮生物合成中的限速酶，可催化二氢乳清酸氧化成乳清酸。DHODH 在癌细胞增殖中起作用。

参考文献

[1]. A K Mohamad Fairus, et al. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. Biochimie. 2017 Apr;135:154-163.
[2]. Hardeep Kaur, et al. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review. Eur J Pharmacol. 2021 Sep 5;906:174233.
[3]. Stepana Boukalova, et al. Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165759.