DNA methyltransferases (DNMTs)

DNA 甲基转移酶

英文解释

DNA methyltransferases (DNMTs) is involved for DNA methylation, which are responsible for adding a methyl group to the fifth carbon atom of the cytosine residues within cytosine-phosphate-guanine (CpG) and non-CpG dinuclotide sites. Five DNMT enzymes have been identified in mammals including DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L. DNMTs can be used for the research of epigenetic mechanisms.

中文解释

DNA 甲基转移酶 (DNMT) 参与 DNA 甲基化 DNA methylation，负责将甲基添加到胞嘧啶-磷酸-鸟嘌呤 (CpG) 和非 CpG 二核苷酸位点内的胞嘧啶残基的第五个碳原子上。 已在哺乳动物中鉴定出五种 DNMT 酶，包括 DNMT1、DNMT2、DNMT3A、DNMT3B 和 DNMT3L。DNMTs 可用于表观遗传机制的研究。

参考文献

[1]. Albert Jeltsch, et al. Editorial-Role of DNA Methyltransferases in the Epigenome.Genes (Basel). 2019 Jul 30;10(8):574.