Enhancer of zeste homolog 2 (EZH2)

zeste 同源物 2 增强子

英文解释

Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of Polycomb repressivecomplex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3). EZH2 could also regulate gene expression in ways besides H3K27me3.

中文解释

zeste 同源物 2 增强子 (EZH2) 是多梳抑制复合体 2 Polycomb repressivecomplex 2 (PRC2) 的酶催化亚基，它可以通过组蛋白 3 (H3K27me3) 中 Lys-27 的三甲基化改变下游靶基因的表达。EZH2 还可以通过 H3K27me3 以外的途径调控基因表达。

参考文献

[1]. Duan R, et al. EZH2: a novel target for cancer treatment. J Hematol Oncol. 2020 Jul 28;13(1):104.