Free fatty acid receptor 2 (FFA2)/GPR43

游离脂肪酸受体 2

英文解释

Free fatty acid receptor 2 (FFA2)/GPR43 is a 7-transmembrane receptor activated by short-chain fatty acids (SCFAs) produced endogenously during colonic fermentation of dietary fiber by the gut microbiota. FFA2/GPR43 is expressed in various cell types such as adipocytes, pancreatic β-cells and immune cells.

中文解释

游离脂肪酸受体 2 (FFA2)/GPR43 是一种 7 跨膜受体，由肠道微生物群在膳食纤维结肠发酵过程中内源性产生的短链脂肪酸 (SCFA) 激活。FFA2/GPR43 在多种细胞类型中表达，例如脂肪细胞、胰腺 β 细胞和免疫细胞。

参考文献

[1]. Anders H?jgaard Hansen, et al. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). J Med Chem. 2017 Jul 13;60(13):5638-5645.