G protein-coupled receptor kinases (GRKs)

G 蛋白偶联受体激酶

英文解释

G protein-coupled receptor kinases (GRKs) are serine/threonine kinases that regulate a large and diverse class of G protein-coupled receptors (GPCRs). GRKs play a critical role in the outcome of a variety of physiological and pathophysiological processes including chemotaxis, signaling, migration, inflammatory gene expression, etc.

中文解释

G 蛋白偶联受体激酶 (GRK) 是调节大量不同类别的 G 蛋白偶联受体 (GPCR) 的丝氨酸/苏氨酸激酶。 GRKs 在各种生理和病理生理过程的结果中起着关键作用，包括趋化性、信号传导、迁移、炎症基因表达等。

参考文献

[1]. Michael D Steury, et al. G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling. Adv Immunol. 2017;136:227-277.