Glutamate dehydrogenase (GLDH,GDH)

谷氨酸脱氢酶 (GLDH, GDH)

英文解释

Glutamate dehydrogenase (GLDH,GDH) is a hexameric enzyme that catalyzes the conversion of glutamate to α-ketoglutarate and ammonia, while reducing NAD(P)+ to NAD(P)H. GDH pathway is linked to diverse cellular processes, including ammonia metabolism, acid-base equilibrium, redox homeostasis , lipid biosynthesis, and lactate production.

中文解释

谷氨酸脱氢酶 (GLDH, GDH) 是一种六聚体酶，可催化谷氨酸转化为 α-酮戊二酸和氨，同时将 NAD(P)+ 还原为 NAD(P)H。GDH 通路与多种细胞过程有关，包括氨代谢、酸碱平衡、氧化还原稳态、脂质生物合成和乳酸生成。

参考文献

[1]. Plaitakis A, et al. The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease. Biology (Basel). 2017 Feb 8;6(1):11.