IκB kinase(IKK)

IκB 激酶

英文解释

IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and immune responses, the activation of the IKK complex also responds to various stimuli to regulate diverse functions independently of NF-κB.

中文解释

IκB 激酶 (IKK) 复合体是 NF-κB 激活的主激酶，包含两个激酶亚基，IKKα 和 IKKβ。除了在炎症和免疫反应中通过磷酸化 IκB 蛋白介导 NF-κB 信号外，IKK 复合体的激活还对各种刺激作出反应，以调节独立于NF-κB的各种功能。

参考文献

[1]. Huang WC, Hung MC. Beyond NF-κB activation: nuclear functions of IκB kinase α. J Biomed Sci. 2013 Jan 23;20(1):3.