Lentiviral vectors (LVs)

慢病毒载体

英文解释

Lentiviral vectors (LVs) is a potent and versatile vectors for ex vivo or in vivo gene transfer into dividing and nondividing cells, forming stable transgene expression. LVs can be pseudotyped with distinct viral envelopes that produce different vector tropism and transduction efficiency. LVs can be targeted by incorporating specific ligands or antibodies into the vector envelope.

中文解释

慢病毒载体 (LV) 是一种有效且用途广泛的载体，用于离体或体内基因转移到分裂和非分裂细胞中，形成稳定的转基因表达。LV 可以用不同的病毒包膜进行假型化，从而产生不同的向量向性和转导效率。可以通过将特定配体或抗体掺入载体包膜来靶向 LV。

参考文献

[1]. Janka Mátrai, et al. Recent advances in lentiviral vector development and applications. Mol Ther. 2010 Mar;18(3):477-90.