Leukemia inhibitory factor (LIF)

白血病抑制因子

英文解释

Leukemia inhibitory factor (LIF) is a multi-functional cytokine of the interleukin-6 (IL-6) superfamily. LIF Initially identified as a factor that inhibits the proliferation of murine myeloid leukemia cells, LIF displays important functions in many physiological and pathological processes, including regulating cell proliferation, pluripotent stem cell self-renewal, tissue/organ development and regeneration, neurogenesis and neural regeneration, maternal reproduction, inflammation, infection, immune response, and metabolism.

中文解释

白血病抑制因子 (LIF) 是白细胞介素 6 (IL-6) 超家族的多功能细胞因子。LIF 最初被确定为抑制小鼠髓系白血病细胞增殖的因子，LIF 在许多生理和病理过程中发挥重要作用，包括调节细胞增殖、多能干细胞自我更新、组织/器官发育和再生、神经发生和神经再生 、母体生殖、炎症、感染、免疫反应和新陈代谢。

参考文献

[1]. Cen Zhang, et al. The emerging role of leukemia inhibitory factor in cancer and therapy. Pharmacol Ther. 2021 May;221:107754.