Mitochondrial SHMT (SHMT2)

线粒体 SHMT

英文解释

Mitochondrial SHMT (SHMT2) is the mitochondrial serine hydroxymethyltransferase, a key enzyme in one-carbon metabolism. Mitochondrial SHMT (SHMT2) may serve as a prognostic marker and a target for anticancer research.

中文解释

线粒体 SHMT (SHMT2)，是线粒体丝氨酸羟甲基转移酶，是单碳代谢的关键酶。线粒体 SHMT 可作为预后标志物和抗肿瘤研究的靶点。

参考文献

[1]. Wilke AC, et al. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022 Jan 27;139(4):538-553.
[2]. Zeng Y, et al. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer. 2021 Aug 8;12(19):5888-5894.