mTOR complex 1 (mTORC1)

mTOR 复合物 1

英文解释

mTOR complex 1 (mTORC1) is the direct target of the clinically important drug Rapamycin, which allosterically inhibits mTORC1. mTORC1 is critical in cell growth, tissue growth, and thus organismal growth of higher organisms.

中文解释

mTOR 复合物 1 (mTORC1) 是临床药物雷帕霉素 (Rapamycin) 的直接靶点，雷帕霉素变构抑制 mTORC1。mTORC1 在细胞生长、组织生长以及高等生物的有机体生长中至关重要。

参考文献

[1]. Szwed A, et al. Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev. 2021 Jul 1;101(3):1371-1426.