Parathyroid hormone type 1 receptor (PTHR1)

甲状旁腺激素受体-1

英文解释

Parathyroid hormone type 1 receptor (PTHR1), a class B G-protein-coupled receptor, is critical for calcium homeostasis and is a therapeutic target for osteoporosis and hypoparathyroidism.PTHR1 affects cell viability, apoptosis, migration, invasion and colony formation, possibly by regulating AGT/CCL9 in osteosarcoma (OS) cells.

中文解释

甲状旁腺激素受体-1 (PTHR1) 是一种B类G蛋白偶联受体，对钙稳态至关重要，是骨质疏松和甲状旁腺功能减退的治疗靶点。甲状旁腺激素受体-1可能通过调节骨肉瘤(OS)细胞中的AGT/CCL9，影响细胞活力、凋亡、迁移、侵袭和菌落形成。

参考文献

[1]. Zhao LH, et al. Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153.
[2]. Li S, et al. Parathyroid hormone type 1 receptor regulates osteosarcoma K7M2 Cell growth by interacting with angiotensinogen. J Cell Mol Med. 2021 Mar;25(6):2841-2850.