Phosphodiesterase (PDE)

磷酸二酯酶

英文解释

Phosphodiesterase (PDE) is key enzymes in the adenosine and guanosine cyclic nucleotides (cAMP and cGMP) signaling cascade, acts by breaking the phosphodiester bond. Phosphodiesterase (PDE) is a large family with multiple genes. The development of selective phosphodiesterase inhibitors will open up new ideas for many diseases research.

中文解释

磷酸二酯酶 (PDE) 是 cAMP 和 cGMP 信号级联中的关键酶，能够破坏它们的磷酸二酯键。磷酸二酯酶是一个多基因大家族，开发选择性的磷酸二酯酶抑制剂将为多种疾病的治疗开辟新的思路。

参考文献

[1]. Martinez A, et al. cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opin Ther Pat. 2014 Dec;24(12):1311-21.