Polynucleotide kinase phosphatase (PNKP1)

多核苷酸激酶磷酸酶

英文解释

Polynucleotide kinase phosphatase (PNKP1) is a critical mammalian DNA repair enzyme. PNKP1 generates 5′-phosphate and 3′-hydroxyl groups at damaged DNA termini that are required for subsequent processing by DNA ligases and polymerases.

中文解释

多核苷酸激酶磷酸酶 (PNKP1) 是一种重要的哺乳动物 DNA 修复酶。 PNKP1 在受损的 DNA 末端产生 5'-磷酸和 3'-羟基，以用于 DNA 连接酶和聚合酶的后续加工。

参考文献

[1]. Coquelle N, et al. Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21022-7.