Pore-forming toxins (PFTs)

成孔毒素

英文解释

Pore-forming toxins (PFTs) are water-soluble molecules that have been identified as the most crucial virulence factors during bacterial pathogenesis. PFTs disrupt the host cell membrane to internalize or to deliver other bacterial or virulence factors for establishing infections. Disruption of the host cell membrane by PFTs can lead to uncontrollable exchanges between the extracellular and the intracellular matrix, thereby disturbing the cellular homeostasis.

中文解释

成孔毒素 (PFTs) 是一种水溶性分子，已被确定为细菌发病过程中最关键的毒力因素。PFTs 破坏宿主细胞膜，使其内化或传递其他细菌或毒力因子，从而引起感染。PFTs 对宿主细胞膜的破坏可导致细胞外和细胞内基质之间不可控的交换，从而扰乱细胞内稳态。

参考文献

[1]. Banerji R, et al. Pore-forming toxins of foodborne pathogens. Compr Rev Food Sci Food Saf. 2021 May;20(3):2265-2285.