Positive allosteric modulators (PAMs)

正变构调节剂

英文解释

Positive allosteric modulators (PAMs)is a allosteric modulator, binding to a receptor to change that receptor's response to stimulus. Positive allosteric modulators (PAMs)increasesthe response of the receptor by increasing the affinity that an agonist will bind to a receptor, increasing its efficacy to activate the receptor, or both.

中文解释

正变构调节剂 (PAMs) 是一种变构调节剂，与受体结合改变受体对刺激的反应。正变构调节剂通过增加激动剂与受体结合的亲和力，增加其激活受体的能力，或两者兼有，来增加受体的反应。

参考文献

[1]. Neubig RR, et al; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 2003 Dec;55(4):597-606.