Post-translational modifications (PTMs)

翻译后修饰

英文解释

Post-translational modifications (PTMs) are an essential regulator of non-functional protein aggregation in the pathogenesis of Neurodegenerative diseases (NDDs). Any alteration in the post-translational mechanism and the protein quality control system, for instance, molecular chaperone, ubiquitin-proteasome system, autophagy-lysosomal degradation pathway, enhances the accumulation of misfolded protein, which causes neuronal dysfunction.

中文解释

翻译后修饰 (PTM) 是神经退行性疾病 神经退行性疾病 发病机制中非功能性蛋白质聚集的重要调节因子。翻译后机制和蛋白质质量控制系统的任何改变，例如分子伴侣、泛素-蛋白酶体系统、自噬-溶酶体降解途径，都会增加错误折叠蛋白质的积累，从而导致神经元功能障碍。

参考文献

[1]. Rohan Gupta, et al. Post-translational modifications: Regulators of neurodegenerative proteinopathies. Ageing Res Rev. 2021 Jul;68:101336.