Presenilin 1 (PS1)

早老素-1

英文解释

Presenilin-1 (PS1) is the major gene responsible for early-onset familial Alzheimer's disease (FAD). To understand the normal function of PS1, we have generated a targeted null mutation in the murine homolog of PS1.

中文解释

早老素-1 (PS1) 是导致早发家族性阿尔茨海默病 (FAD) 的主要基因。为了了解 PS1 的正常功能，我们在小鼠中产生了 PS1 的同源物的靶向零突变。

参考文献

[1]. Shen J, et al. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 1997 May 16;89(4):629-39.