Presenilin 2 (PS2)

早老素-2

英文解释

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer's disease (FAD). It forms the catalytic core of the γ-secretase , independently of γ-secretase activity, in the modulation of several cellular processes, such as Ca2+?signalling, mitochondrial function, inter-organelle communication, and autophagy.

中文解释

早老素-2 (PS2) 是家族性阿尔茨海默病 (FAD) 中主要突变的三种蛋白质之一。它形成了 γ-分泌酶的催化核心，独立于 γ-分泌酶活性，调节几个细胞过程，如 Ca2+ 信号，线粒体功能，细胞器间通信和自噬。

参考文献

[1]. Pizzo P, et al. Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks. Cells. 2020 Sep 25;9(10):2166.