Primary myelofibrosis (PMF)

原发性骨髓纤维化

英文解释

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell-derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival.

中文解释

原发性骨髓纤维化 (PMF) 是一种以干细胞来源的克隆性骨髓增生、细胞因子异常表达、骨髓纤维化、贫血、脾肿大、髓外造血 (EMH)、体质症状、恶病质、白血病进展和缩短生存期为特征的骨髓增生性肿瘤。

参考文献

[1]. Tefferi A. Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol. 2014 Sep;89(9):915-25.