Proteolysis targeting chimera (PROTAC)

蛋白水解靶向嵌合体

英文解释

Proteolysis targeting chimera (PROTAC) is a kind of bifunctional small molecule, in which the target protein ligand and the E3 ubiquitin ligases (E3) ubiquitin ligase ligand are linked together through a linker to form a triplet compound.

中文解释

蛋白水解靶向嵌合体 (PROTAC) 是一种双功能小分子，其靶蛋白配体与 E3 ubiquitin ligases (E3) 泛素连接酶配体通过连接子连接在一起形成三元化合物。

参考文献

[1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 Jun 10;64(11):7839-7852.