Serine hydroxymethyltransferase (SHMT)

丝氨酸羟甲基转移酶

英文解释

Serine hydroxymethyltransferase (SHMT) is a key mitochondrial enzyme in serine catabolism that converts serine to glycine and a one-carbon unit that yields S-adenosyl methionine (SAM) and NADPH through the folic acid and methionine cycles.

中文解释

丝氨酸羟甲基转移酶 (SHMT) 是丝氨酸分解代谢中的一个关键线粒体酶，它将丝氨酸转化为甘氨酸和一个单碳单位，通过叶酸 folic acid 和蛋氨酸循环产生 S-腺苷蛋氨酸 (SAM) 和 NADPH。

参考文献

[1]. Parsa S, et al. The serinehydroxymethyltransferase-2 (SHMT2) initiates lymphoma development throughepigenetic tumor suppressor silencing. Nat Cancer. 2020;1:653-664.