Serine hydroxymethyltransferse (SHMT)

丝氨酸羟甲基转移酶

英文解释

Serine hydroxymethyltransferse (SHMT) is a pyridoxal phosphate (Vitamin B6) dependent enzyme, plays an important role in cellular one-carbon pathways. Serine hydroxymethyltransferse (SHMT) catalyzes the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF).

中文解释

丝氨酸羟甲基转移酶 (SHMT)，是一种依赖于磷酸吡哆醛 (维生素 B6) 的酶，在细胞单碳通路中有重要作用。丝氨酸羟甲基转移催化 L-丝氨酸向甘氨酸和四氢叶酸 (THF) 向 5,10-亚甲基四氢叶酸的可逆同时转化。

参考文献

[1]. Florio R, et al. Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies. Biochim Biophys Acta. 2011 Nov;1814(11):1489-96.
[2]. Appaji Rao N, et al. Structure-function relationship in serine hydroxymethyltransferase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):24-9.