Serine synthesis pathway (SSP)

丝氨酸合成途径

英文解释

Serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable for cancer cells to grow in serine-limiting environments.

中文解释

丝氨酸合成途径 (SSP) 包括代谢酶磷酸甘油酸脱氢酶 (PHGDH)、磷酸丝氨酸转氨酶1 (PSAT1) 和磷酸丝氨酸磷酸酶 (PSPH) 驱动细胞内丝氨酸生物合成，是癌细胞在丝氨酸限制环境中生长所不可或缺的。

参考文献

[1]. Li X, et al. ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction. Cell Rep. 2021 Sep 21;36(12):109706.