Small interfering RNA (siRNA)

小干扰 RNA

英文解释

Small-interfering RNA (siRNA), synthetic double-stranded RNA consisting of approximately 21 base pairs, suppresses problematic target genes in a sequence-specific manner via inherent RNA interference (RNAi) processing. As a result, siRNA offers a potential strategy for treatment of many human diseases.

中文解释

小干扰 RNA (siRNA) 是一种合成的双链 RNA，由大约 21 个碱基对组成，通过固有 RNA 干扰 (RNAi) 处理以特定序列的方式抑制有问题的靶基因。因此，siRNA 为许多人类疾病的治疗提供了一种潜在的策略。

参考文献

[1]. Lee SH, et al. Small-interfering RNA (siRNA)-based functional micro- and nanostructures for efficient and selective gene silencing. Acc Chem Res. 2012 Jul 17;45(7):1014-25.