Spike protein

刺突蛋白

英文解释

Spike protein is the spike (S) protein of? Severe acute respiratory syndrome coronavirus-2(SARS CoV-2), which plays a key role in the receptor recognition and cell membrane fusion process. Spike protein is composed of two subunits, S1 and S2. S1 recognizes and binds to the host receptor angiotensin-converting enzyme 2 (ACE2), while S2 mediates viral cell membrane fusion.

中文解释

刺突蛋白是 Severe acute respiratory syndrome coronavirus-2(SARS CoV-2) 的 S 蛋白部分，在受体识别和细胞膜融合过程中起关键作用。刺突蛋白由两个亚基 S1 和 S2 组成。S1 识别并结合宿主受体血管紧张素转换酶 2 (ACE2)，而 S2 介导病毒细胞膜融合。

参考文献

[1]. Huang Y, et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149.