Type II DNA topoisomerase (topo II)

II 型 DNA 拓扑异构酶

英文解释

Type II DNA topoisomerase (topo II) is a type IIA topoisomerase that can relax both positively and negatively supercoiled DNA in an ATP- and Mg2+-dependent manner. Topo II is required for the condensation, maintenance of structure, and segregation of daughter chromosomes following DNA replication, and it has also been linked to chromosome condensation during apoptosis in mammals.

中文解释

II 型 DNA 拓扑异构酶 (topo II) 是一种 IIA 型拓扑异构酶，可以以 ATP 和 Mg2+ 依赖的方式放松正和负超螺旋 DNA。Topo II 是 DNA 复制后子染色体的凝聚、结构维持和分离所必需的，它也与哺乳动物细胞凋亡过程中的染色体凝聚有关。

参考文献

[1]. Bush NG, et al. DNA Topoisomerases. EcoSal Plus. 2015;6(2). doi: 10.1128/ecosalplus.