Type II transmembrane serine proteases (TTSPs)
发布时间:2023-03-22 22:08:39
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Type II transmembrane serine proteases (TTSPs)
II 型跨膜丝氨酸蛋白酶
英文解释
Type II transmembrane serine proteases (TTSPs)?are an N-terminal transmembrane domain, a C-terminal extracellular serine protease domain of the chymotrypsin (S1) fold that contains the catalytic histidine, aspartic acid, and serine residues, and a “stem region” that may contain an assortment of 1-11 protein domains of six different types. Type II transmembrane serine proteases (TTSPs)?could function as initiators of proteolytic cascades.
中文解释
II 型跨膜丝氨酸蛋白酶 (TTSPs) 是凝乳胰蛋白酶 (S1) 褶的一个 N 端跨膜结构域,一个 C 端胞外丝氨酸蛋白酶结构域,其中包含催化组氨酸、天冬氨酸和丝氨酸残基,以及一个“茎区”,其中可能包含6种不同类型的 1-11 个蛋白质结构域。II 型跨膜丝氨酸蛋白酶可作为蛋白水解级联的启动物。
参考文献
[1]. Bugge TH, et al. Type II transmembrane serine proteases. J Biol Chem. 2009 Aug 28;284(35):23177-81.