Type-1-insulin-like growth factor receptor (IGF-1R)

1 型胰岛素样生长因子受体

英文解释

The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular alpha subunits and two beta subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated in cancers and promotes proliferation and cell survival.

中文解释

1 型胰岛素样生长因子受体 (IGF-1R) 是一种跨膜糖蛋白，由两个细胞外 α 亚基和两个具有酪氨酸激酶活性的 β 亚基组成。IGF-1R 在癌症中经常上调并促进增殖和细胞存活。

参考文献

[1]. Tamara Aleksic, et al. Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 2010 Aug 15;70(16):6412-9.