Ubiquitin-proteasome system (UPS)

泛素-蛋白酶体系统

英文解释

Ubiquitin-proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner. The critical importance of the UPS is particularly visible in immune cells which undergo a rapid and profound functional remodelling upon pathogen recognition. Innate and/or adaptive immune activation is indeed characterized by a number of substantial changes impacting various cellular processes including protein homeostasis, signal transduction, cell proliferation, and antigen processing.

中文解释

泛素-蛋白酶体系统 (UPS) 是细胞内和非溶酶体蛋白质降解的主要系统。由于其独特的能力，消除旧的，损坏的，错误折叠，和/或调节蛋白以高度特定的方式。UPS 的关键重要性在免疫细胞中特别明显，免疫细胞在病原体识别后经历快速而深刻的功能重塑。先天和/或适应性免疫激活的特征确实是影响各种细胞过程的许多实质性变化，包括蛋白质稳态、信号转导、细胞增殖和抗原处理。

参考文献

[1]. ?etin G, et al. The Ubiquitin-Proteasome System in Immune Cells. Biomolecules. 2021 Jan 5;11(1):60.