Aldehyde dehydrogenase 2 (ALDH2)

乙醛脱氢酶 2

英文解释

Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of the alcohol metabolite acetaldehyde in the liver.Additionally, ALDH2 is involved in the elimination of metabolites of neurotransmitters like 3,4-dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycoaldehyde (DOPGAL) in the central nervous system (CNS).

中文解释

乙醛脱氢酶 2 (ALDH2) 是肝脏中负责酒精代谢物乙醛代谢的关键酶。此外，ALDH2 还参与消除中枢神经系统 (CNS) 中的神经递质代谢物，如 3,4-二羟基苯乙醛 (DOPAL) 和3,4-二羟基苯乙醛 (DOPGAL)。

参考文献

[1]. Wang W, et al. Aldehyde Dehydrogenase, Liver Disease and Cancer. Int J Biol Sci. 2020 Jan 22;16(6):921-934.
[2]. Kimura M, et al. Aldehyde dehydrogenase-2 as a therapeutic target. Expert Opin Ther Targets. 2019 Nov;23(11):955-966.