Sphingosine 1-phosphate (S1P)

1-磷酸鞘氨醇

英文解释

Sphingosine 1-phosphate (S1P) is a a variety of Sphingolipids (SFs) metabolites capable of performing various biological activities. S1P is commonly found in platelets, red blood cells, neutrophils, lymph fluid, and blood, as well as other cells and body fluids. S1P comprises five receptors, namely, S1P1-S1P5, with the distribution of S1P receptors exhibiting tissue selectivity to some degree. S1P1, S1P2, and S1P3 are extensively expressed in a wide variety of different tissues. The expression of S1P4 is restricted to lymphoid and hematopoietic tissues, while S1P5 is primarily expressed in the nervous system. S1P3 plays an essential role in the pathophysiological processes related to inflammation, cell proliferation, cell migration, tumor invasion and metastasis, ischemia-reperfusion, tissue fibrosis, and vascular tone.

中文解释

1-磷酸鞘氨醇 (S1P) 是一种能够发挥各种生物活性的多种鞘脂 Sphingolipids (SFs) 代谢物。S1P 常见于血小板、红细胞、中性粒细胞、淋巴液和血液，以及其他细胞和体液中。S1P 包含 5 种受体，即S1P1-S1P5，S1P 受体的分布在一定程度上表现出组织选择性。S1P1、S1P2 和 S1P3 在多种不同组织中广泛表达。S1P4 的表达仅限于淋巴和造血组织，而 S1P5 主要在神经系统中表达。S1P3 在与炎症、细胞增殖、细胞迁移、肿瘤侵袭和转移、缺血再灌注、组织纤维化和血管张力相关的病理生理过程中起重要作用。

参考文献

[1]. Xuehui Fan, et al. Recent advances of the function of sphingosine 1-phosphate (S1P) receptor S1P3. J Cell Physiol. 2021 Mar;236(3):1564-1578.