4-(1,2-Dihydroxyethyl)benzene-1,2-diol
An active metabolite of norepinephrine
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包装价格促销价数量
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10mg￥1612.001290.00- +
- 货号: ajce47522
- CAS: 28822-73-3
- 别名: DL-3,4-二羟基苯基二醇
- 分子式: C8H10O4
- 分子量: 170.16
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine .1 It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol.2 DL-3,4-Dihydroxyphenyl glycol scavenges DPPH radicals in a cell-free assay (IC50 = 1.55 ?M).3 It reduces LPS-induced nitrite production in isolated mouse peritoneal macrophages when used at concentrations of 50 and 100 ?M. DL-3,4-Dihydroxyphenyl glycol (50 and 100 ?M) decreases increases in inducible nitric oxide synthase (iNOS) and COX-2 levels induced by LPS in isolated mouse macrophages. It also inhibits LPS-induced degradation of IκBα in isolated mouse macrophages.
1.Jonason, J., and Rutledge, C.O.The effect of protriptyline on the metabolism of dopamine and noradrenaline in rabbit brain in vitroActa Physiol. Scand.73(1)161-175(1968) 2.Padala, N.S.P., Ajjala, D.R., Boggavarapu, R.K., et al.LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regionsBioanalysis11(10)971-986(2019) 3.Aparicio-Soto, M., Sánchez-Fidalgo, S., González-Benjumea, A., et al.Naturally occurring hydroxytyrosol derivatives: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplementsJ. Agric. Food Chem.63(3)836-846(2015)
