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Methylnissolin
A flavonoid with antiproliferative activity
(S)-p38 MAPK Inhibitor III
A cell-permeable p38 MAP kinase inhibitor
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inf
PF-06260933
A MAP4K4 inhibitor
TCS JNK 6o
A JNK inhibitor
NQDI 1
A selective inhibitor of ASK1
ITX5061
ITX5061是一个II型p38MAPK抑制剂,也是清道夫受体B1(SR-B1)的拮抗剂。
U-0126
A MEK inhibitor and AMPK activator
Cobimetinib
A potent, orally available MEK1 inhibitor
BAY885
PD 198306
A potent inhibitor of MEK1/2
Pimasertib (AS-703026)
A MEK1/2 inhibitor
PLX8394
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
SP 600125
A pan-JNK inhibitor
GNE-495
An orally bioavailable, potent, and selective MAP4K4 inhibitor