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Pemigatinib
An FGFR inhibitor
ASP5878
ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.
Nintedanib esylate
Nintedanib esylate, as a kinase inhibitor, used for the treatment of non-small cell lung cancer suffered from first-pass metabolism which resulted in low oral bioavailability .
ACTB-1003
A multi-kinase inhibitor
Rogaratinib (BAY1163877)
Rogaratinib (BAY1163877) (BAY1163877) 是一种有效的选择性成纤维细胞生长因子受体 (FGFR) 抑制剂。
AZ-23 (AZ23)
AZ-23 (AZ23) 是一种 ATP 竞争性和口服生物可利用的 Trk 激酶 A/B/C 抑制剂,IC50 为 2 nM (TrkA)、8 nM (TrkB)、24 nM (FGFR1)、52 nM (Flt3)、55分别为 nM (Ret)、84 nM (MuSk)、99 nM (Lck)。
AZD4547
A selective inhibitor of FGFR tyrosine kinases
Tyrosine kinase-IN-1
Tyrosinekinase-IN-1是多靶点的酪氨酸激酶抑制剂,抑制KDR,Flt-1,FGFR1和PDGFRα的IC50值分别为4,20,4,2nM。
FIIN-3
An inhibitor of FGFRs
PP58
PP58是吡啶[2,3-d]嘧啶化合物,抑制PDGFR,FGFR和Src家族活性的IC50值在纳摩尔级。
TG 100572
TG 100572是多靶点激酶抑制剂,抑制受体酪氨酸激酶 (receptor tyrosine kinases) 和Src激酶 (Src kinases); 对VEGFR1,VEGFR2,FGFR1,FGFR2,PDGFRβ,Fgr,Fyn,Hck,Lck,Lyn,Src,Yes 的 IC50 值分别为2,7,2,16,13,5,0.5,6,0.1,0.4,1,0.2 nM。
SU 5402
An inhibitor of VEGFR2, FGFR1, and PDGFRβ
Lenvatinib mesylate
An inhibitor of VEGFR2 and VEGFR3
TAS-120
An orally bioavailable, irreversible inhibitor of FGFRs
TG 100801 Hydrochloride
TG 100801 Hydrochloride 是TG 100572的前药,通过去酯化产生TG 100572,开发用来治疗年龄相关的黄斑变性。TG 100572是多靶点激酶抑制剂,抑制受体酪氨酸激酶 (receptor tyrosine kinases) 和Src激酶 (Src kinases); 对VEGFR1,VEGFR2,FGFR1,FGFR2,PDGFRβ,Fgr,Fyn,Hck,Lck,Lyn,Src,Yes 的 IC50 值分别为2,7,2,16,13,5,0.5,6,0.1,0.4,1,0.