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MT-802
MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S
Vecabrutinib (SNS-062)
Vecabrutinib (SNS-062) (SNS-062) 是一种有效的非共价 BTK 和 ITK 抑制剂,Kd 值分别为 0.3 nM 和 2.2 nM。 Vecabrutinib (SNS-062) 对 ITK 的 IC50 为 24 nM。
ARQ 531
Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from T
Btk inhibitor 1
(Rac)-IBT6A (BTK inhibitor 1) is a racemate of IBT6A and an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
Btk inhibitor 1 R enantiomer hydrochloride
Btk inhibitor 1 R enantiomer hydrochloride 是依鲁替尼的杂质。 IBT6A 可用于 IBT6A 依鲁替尼二聚体和 IBT6A 加合物的合成。 Ibrutinib 是一种选择性、不可逆的 Btk 抑制剂,IC50 为 0.5 nM。
Ibrutinib-biotin
Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针,具体可参考 WO2014059368A1 中 Compound 1-5,抑制 BTK,IC50 值为 0.755-1.02 nM。
Lck inhibitor 2
Lck inhibitor 2是多靶点酪氨酸激酶抑制剂,对Lck,Btk,Lyn,Btk和Txk的IC50分别为13nM,9nM,3nM,26nM和2nM。
CHMFL-BTK-01
CHMFL-BTK-01 (compound 9) 高度选择性的、不可逆的 BTK 抑制剂,IC50 值为 7 nM。CHMFL-BTK-01 (compound 9) 可有效抑制BTK Y223 的自磷酸化。
LFM-A13
A BTK inhibitor
PCI 29732
A multi-kinase inhibitor
Tirabrutinib hydrochloride (ONO-4059 (hydrochloride))
PF-06250112
PF-06250112是一种有效的、高度选择性、口服有效的BTK抑制剂,IC50值为0.5nM,对BMX非受体酪氨酸激酶和TEC同样有抑制作用,IC50值分别为0.9nM和1.2nM。
Spebrutinib besylate
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) 是共价,高选择性和口服活性的 Btk 抑制剂,IC50 为0.5 nM。
PCI-32765 (Ibrutinib)
PCI-32765 (Ibrutinib) is an irreversible selective inhibitor of Bruton s tyrosine kinase (BTK) that selectively targets its kinase domain.
QL47
QL47不可逆的BTK抑制剂,IC50为7 nM。